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KMID : 0360319940260060936
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 6 p.936 ~ p.942
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Expression of mn23-Hl in Breast Cancer and Its Clinical Significance
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한세환
노동영/허진석/최국진/송상용/지제근
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Abstract
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The nm23H1 gene, identified from murine melanoma cell line, is located in the chromosome 17q22. Its meaning as an anti-metastatic marker was potentiated by the fact that the transfection of nm23-H1 gene into a murine melanoma cell line with high
metastatic potential resulted in a change to decreased metastatic capability. This study was designed to determine the frequency of nm23 protein expression in human breast carcinoma and to compare its result with other established prognostic
parameters.
We studied 88 breast carcinoma samples for the expression of anti-nm23/nucleoside diphosphate kinase A using immunohistochemical analysis. All the patients were female and 7 cases(8%) were not stained immunohistochemically. Among the positively
stained
group, 43 cases(48.9%) were weakly positive and 38 cases(43.2%) were stained strongly. Expression of nm23 decreased significantly as the tumor size increased and in axillary lymph node metastasis group. There was decreasing tendency of nm23
expression
as the nuclear grade increased. Estrogen receptor status or menopausal status did nct correlate with nm23 expression. The diseased free survival rate was superior in the group with strongly positive expression of nm23. In conclusion, the results
suggest
that expression of nm23 protein may have a role in the suppression of lymph node metastasis in breast carcinoma.
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KEYWORD
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